2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W011777R
    Tricaine methanesulfonate (Standard) 886-86-2
    Tricaine (methanesulfonate) (Standard) is the analytical standard of Tricaine (methanesulfonate). This product is intended for research and analytical applications. Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures.
    Tricaine methanesulfonate (Standard)
  • HY-W011873A
    Palmitoleic acid sodium 6610-24-8 98%
    Palmitoleic acid sodium, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
    Palmitoleic acid sodium
  • HY-W011873R
    Palmitoleic acid (Standard) 373-49-9
    Pazopanib (Hydrochloride) (Standard) is the analytical standard of Pazopanib (Hydrochloride). This product is intended for research and analytical applications. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
    Palmitoleic acid (Standard)
  • HY-W011873S
    Palmitoleic acid-d14 184708-66-5 98%
    Palmitoleic acid-d14 is the deuterium labeled Palmitoleic acid. Palmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats.
    Palmitoleic acid-d14
  • HY-W011956R
    6-Hydroxymelatonin (Standard) 2208-41-5
    6-Hydroxymelatonin (Standard) is the analytical standard of 6-Hydroxymelatonin. This product is intended for research and analytical applications. 6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.
    6-Hydroxymelatonin (Standard)
  • HY-W012481S
    Nirvanol-d5 119458-27-4 98%
    Nirvanol-d5 (Ethylphenylhydantoin-d5) is deuterium labeled Nirvanol (HY-W012481). Nirvanol (Ethylphenylhydantoin) is a metabolite of Mephenytoin (HY-B1184) that exerts anticonvulsant effects in the maximal electroshock (M.E.S.) seizure model in mice. Nirvanol shows potential for research in epilepsy-related neurological disorders.
    Nirvanol-d5
  • HY-W012922R
    2-Methyl-4-pentenoic Acid (Standard) 1575-74-2
    2-Methyl-4-pentenoic Acid (Standard) (2-Methylpent-4-enoic acid (Standard)) is the analytical standard of 2-Methyl-4-pentenoic Acid (HY-W012922). This product is intended for research and analytical applications. 2-Methyl-4-pentenoic Acid (2-Methylpent-4-enoic acid) is an organic acid that can be used as a precursor for synthesizing other compounds. Additionally, changes in the level of 2-Methyl-4-pentenoic Acid may be associated with the susceptibility to schizophrenia and type 2 diabetes.
    2-Methyl-4-pentenoic Acid (Standard)
  • HY-W013075R
    Rutin trihydrate (Standard) 250249-75-3
    Rutin (trihydrate) (Standard) is the analytical standard of Rutin (trihydrate). This product is intended for research and analytical applications. Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .
    Rutin trihydrate (Standard)
  • HY-W013375S
    Thiorphan-d7 1276297-68-7 98%
    Thiorphan-d7 is the deuterium labeled Thiorphan. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM.
    Thiorphan-d7
  • HY-W013507R
    (rac)-Methyl jasmonate (Standard) 39924-52-2
    (rac)-Methyl jasmonate (Standard) is the analytical standard of Methyl jasmonate. This product is intended for research and analytical applications. (rac)-Methyl jasmonate is the racemate of Methyl jasmonate (HY-135663). Methyl jasmonate is a phytohormone that regulates the defense response of plants under biotic and biotic stress through jasmonate signaling pathway. Methyl jasmonate inhibits the activation of NF-κB signaling pathway. Methyl jasmonate can promote the mitochondrial ROS production, but also scavenges free radicals and reduces the oxidative stress. Methyl jasmonate exhibits anti-inflammatory, antitumor, anticonvulsant, antinociceptive and sedative activities.
    (rac)-Methyl jasmonate (Standard)
  • HY-W013573R
    S-Allyl-L-cysteine (Standard) 21593-77-1
    S-Allyl-L-cysteine (Standard) is the analytical standard of S-Allyl-L-cysteine. This product is intended for research and analytical applications. S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity.
    S-Allyl-L-cysteine (Standard)
  • HY-W013788R
    2-Palmitoylglycerol (Standard) 23470-00-0
    2-Palmitoylglycerol (Standard) is the analytical standard of 2-Palmitoylglycerol. This product is intended for research and analytical applications. 2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119.
    2-Palmitoylglycerol (Standard)
  • HY-W014589S
    2,4-Di-tert-butylphenol-d19 1577233-55-6 98%
    2,4-Di-tert-butylphenol-d19 (2,4-DTBP-d19) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances.
    2,4-Di-tert-butylphenol-d19
  • HY-W015026R
    Isobutylparaben (Standard) 4247-02-3
    Isobutylparaben (Standard) is the analytical standard of Isobutylparaben. This product is intended for research and analytical applications. Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics.
    Isobutylparaben (Standard)
  • HY-W015026S
    Isobutylparaben-d4 1219805-33-0 98%
    Isobutylparaben-d4 is the deuterium labeled Isobutylparaben. Isobutylparaben (Isobutyl 4-hydroxybenzoate) is the agonist for PXR, CAR and PPAR. Isobutylparaben has a broad-spectrum antimicrobial activity and widely used in personal care products and cosmetics.
    Isobutylparaben-d4
  • HY-W015788R
    1-Phenylethane-1,2-diol (Standard) 93-56-1
    1-Phenylethane-1,2-diol (Standard) is the analytical standard of 1-Phenylethane-1,2-diol. This product is intended for research and analytical applications. 1-Phenylethane-1,2-diol (Styrene Glycol) is a benzyl diol compound, which is the major metabolite of Styrene. 1-Phenylethane-1,2-diol can be oxidized to hydroxyl ketone (2-hydroxy-1-phenylethan-1-one) selectively with variety of catalysts, including organocatalysts, metal complexes, non-noble metal oxides, bimetallics[1][2][3].
    1-Phenylethane-1,2-diol (Standard)
  • HY-W015878R
    5-Aminovaleric acid (Standard) 660-88-8
    5-Aminovaleric acid (Standard) is the analytical standard of 5-Aminovaleric acid. This product is intended for research and analytical applications. 5-Aminovaleric acid is believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist.
    5-Aminovaleric acid (Standard)
  • HY-W016194R
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) 67950-95-2
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard) is the analytical standard of 1-(Carboxymethyl)cyclohexanecarboxylic acid. This product is intended for research and analytical applications. 1-(Carboxymethyl)cyclohexanecarboxylic acid (1-Carboxycyclohexaneacetic acid; Gabapentin Impurity E) is a potential impurity in commercial preparations of the antiepileptic agent Gabapentin (HY-A0057). It is also used as a precursor for the synthesis of a serotonin (5-HT) receptor subtype 5-HT2A antagonist.
    1-(Carboxymethyl)cyclohexanecarboxylic acid (Standard)
  • HY-W017277R
    (+)-Menthol (Standard) 15356-60-2
    (+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells.
    (+)-Menthol (Standard)
  • HY-W017443R
    L-Asparagine monohydrate (Standard) 5794-13-8
    L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate (HY-W017443). This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine monohydrate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity